Pharmacology & Toxicology Research

Neuroscience, Drugs of Abuse, and Pain

Overview

  • Many investigators in the Department of Pharmacology & Toxicology focus their research on drugs of abuse, pain, and broader aspects of neuroscience with the goal of advancing our understanding in these critical areas.
  • Both faculty and trainees are recognized nationally and internationally for their contributions.

Training and Funding

  • Robust predoctoral and postdoctoral training programs exist in these areas, including NIH-funded T32 training grants on Alcohol and Drugs of Abuse. The latter has been continuously funded for over 50 years!

Research Approaches

  • Investigators use a variety of approaches and models, using molecular, genetic, behavioral, and integrated approaches to study the mechanisms of action and addiction liability of abused drugs and the biology of tolerance and dependence.
  • These studies include research on cannabinoids, opioids, nicotine, ethanol, cocaine, inhalants, and other novel abused drugs.

Major Research Centers

  • There are two significant research centers focused in these areas housed in the department: The Central Virginia Center on Drug Abuse Research promotes innovative basic and clinical research through four research cores and the VCU Alcohol Research Center: continuously funded for over 15 years by the NIAAA is focused on identifying gene networks and brain mechanisms involved in Alcohol Use Disorder.

 

Faculty Research Interests

Dr. Hamid Akbarali PhD

Hamid Akbarali, Ph.D., Professor

Detailed research overview for Dr. Hamid Akbarali

  • The role of the gastrointestinal microbiome in opioid tolerance and hyperalgesia
  • Chemotherapy–induced gastrointestinal toxicity

Dr. Matthew Banks PhD PharmD

Matthew L. Banks, Ph.D., Professor

Detailed research overview for Dr. Matthew L. Banks

  • Medications development for opioid and psychostimulant addiction
  • Development of translational preclinical models of substance use disorders
  • Neurobiological mechanisms of decision-making or “choice” between two reinforcers
  • Influence of environmental variables on addictive drug reinforcement

Dr. Jill Bettinger PhD

Jill C. Bettinger, Ph.D., Professor

Detailed research overview for Dr. Jill Bettinger

  • Alcohol effects on the nervous system
  • State-dependent learning

Dr. Darlene Brunzell PhD

Darlene H. Brunzell, Ph.D., Associate Professor

Detailed research overview for Dr. Darlene Brunzell

  • Neuropharmacology of drugs of abuse and mental illness
  • Mechanisms of learning and memory
  • Developmental Toxicology
  • Sex differences

Dr. Imad Damaj PhD

M. Imad Damaj, Ph.D., Professor

Detailed research overview for Dr. Imad Damaj

  • Drugs of abuse
  • Molecular neuroscience
  • Behavioral pharmacology

Dr. Andrew Davies PhD

Andrew G. Davies, Ph.D., Associate Professor

Detailed research overview for Dr. Andrew Davies

  • Genetics and neurobiology of alcohol intoxication and tolerance
  • Caenorhabditis elegans genetics
  • Cross-species identification of genes contributing to predisposition to alcohol use disorders

Dr. William Dewey PhD

William L. Dewey, Ph.D., Professor

Detailed research overview for Dr. William Dewey

  • Investigation of the similarities of the effects of opioids on brain  and gastrointestinal functions.
  • Elucidate the role of protein kinase A (PKA), protein kinase C (PKC), and related peptides on opioid-induced pain relief, tolerance and dependence
  • Elucidate the pharmacological profile of newly synthesized agents, concentrating  on pain relief and the development of tolerance and physical dependence.
  • Pharmacological similarities and difference between alcohol and opioids, concentrating on pain relief, tolerance and physical dependence

Dr. Andrew George PhD

Andrew A. George, Ph.D., Assistant Professor

Detailed research overview for Dr. Andrew George

  • Ion channel structure and function
  • Alzheimer's disease
  • Neurodegeneration
  • amyloid-induced alterations in neuronal and network-level excitability

Dr. Javier González-Maeso PhD

Javier González-Maeso, Ph.D., Professor

Detailed research overview for Dr. Javier González-Maeso

  • G protein-coupled receptors (GPCRs) and G proteins
  • Psychedelics
  • Molecular Psychiatry
  • Preclinical models of psychiatric and substance use disorders
  • Molecular Pharmacology 

Dr. Kurt Hauser PhD

Kurt F. Hauser, Ph.D., Professor

Detailed research overview for Dr. Kurt Hauser

  • neuroAIDS
  • drug-induced modulation of HIV type 1
  • glial biology
  • neuroimmunology
  • NeuroHIV

Dr. Lankupalle Jayanthi PhD

Lankupalle D. Jayanthi, Ph.D., Professor

Detailed research overview for Dr. Lankupalle Jayanthi

  • Monoaminergic system plasticity in neuropsychiatric conditions including mood disorders and substance use.
  • Monoamine transporters (MATs: NET, DAT and SERT) and their regulation at the molecular and cellular levels.
  • The relationship between MAT regulation and the neuronal signals and brain circuitry that affect animal behavior in normal and pathophysiological states using novel strategies and interdisciplinary approaches

Dr. Amy Lasek, PhD

Amy W. Lasek, Ph.D., Professor

Detailed research overview for Dr. Amy Lasek

  • Brain extracellular matrix and perineuronal nets in neural plasticity and compulsive alcohol drinking
  • Estrogen contributions to sex differences in alcohol drinking 
  • Alcohol-induced transcriptional and epigenetic changes in astrocytes that contribute to alcohol use disorder

Dr. Aron Lichtman

Aron H. Lichtman, Ph.D., Professor

Detailed research overview for Dr. Aron Lichtman

  • Cannabinoids
  • Drugs of abuse
  • Learning and memory
  • Pain and inflammation

Dr. Laura Mathies PhD

Laura D. Mathies, Ph.D., Associate Professor

Detailed research overview for Dr. Laura Mathies

  • SWI/SNF chromatin remodeling in the acute alcohol response
  • SWI/SNF chromatin remodeling in multipotency

Dr. Michael Miles, MD PhD

Michael F. Miles, M.D., Ph.D., Professor

Detailed research overview for Dr. Michael Miles

  • Molecular mechanisms underlying role of prefrontal cortex in progressive ethanol consumption
  • Role of Gsk3b in ethanol consumption and as a potential target for therapeutic intervention in alcohol use disorder
  • Role of myelin-related gene expression in genetic risk for alcohol use disorder and ethanol-related brain or peripheral nerve pathology
  • Genetics of ethanol induced analgesia

Dr. Stevens Negus PhD

S. Stevens Negus, Ph.D., Professor

Detailed research overview for Dr. Stevens Negus

  • Development of new medications to treat pain
  • Development of new medications to treat addiction
  • Development of novel procedures to assess analgesic and addictive drug effects
  • Behavioral pharmacology

Dr. Katherine Nicholson PhD DVM

Katherine L. Nicholson, Ph.D., D.V.M., Associate Professor

Detailed research overview for Dr. Katherine Nicholson

  • Behavioral pharmacology of drugs of abuse

Dr. Sammanda Ramamoorthy PhD

Sammanda Ramamoorthy, Ph.D., Professor

Detailed research overview for Dr. Sammanda Ramamoorthy

  • role of monoamine transporters in mental illness, drug abuse, aging, and neurodegenerative diseases

Dr. Joel Schlosburg PhD

Joel E. Schlosburg, Ph.D., Assistant Professor

Detailed research overview for Dr. Joel Schlosburg

  • cannabinoids, opioids, and drugs of abuse
  • endocannabinoid system in reward/stress
  • stress resilience and comorbid factors in drug taking

Dr. Dana Selley PhD

Dana E. Selley, Ph.D., Professor

Detailed research overview for Dr. Dana Selley

  • cellular tolerance and dependence
  • mechanisms of action of opiates, cannabinoids, and alcohol
  • G protein-mediated signal transduction

Dr. Keith Shelton PhD

Keith L. Shelton, Ph.D., Associate Professor

Detailed research overview for Dr. Keith Shelton

  • Behavioral and neurochemical mechanisms of drug reinforcement and relapse
  • Abuse-related behavioral effects of drug aerosols and vapors
  • Stimulant and opioid relapse-prevention medication development

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Laura J. Sim-Selley, Ph.D., Professor

Detailed research overview for Dr. Laura Sim-Selley

  • Functional neuroanatomy of G-protein-coupled receptors
  • Opioid and cannabinoid receptors
  • Tolerance and dependence

Dr. Matthew Walentiny PhD

D. Matthew Walentiny, Ph.D., Assistant Professor

Detailed research overview for Dr. Matthew Walentiny

  • Behavioral pharmacology of drugs of abuse
  • Preclinical testing of candidate medications for substance abuse disorders

Dr. Paul Whiteaker PhD

Paul Whiteaker, Ph.D., Professor

Detailed research overview for Dr. Paul Whiteaker

  • Nicotinic receptor signaling

Dr. Jennifer Wolstenholme PhD

Jennifer T. Wolstenholme, Ph.D., Associate Professor

Detailed research overview for Dr. Jennifer Wolstenholme

  • drugs of abuse and social stress
  • neuroendocrinology
  • sex differences within the brain and behavior
  • critical developmental windows of susceptibility for adult-onset disorders

Dr. Viktor Yarotskyy PhD

Viktor Yarotskyy, Ph.D., Assistant Professor

Detailed research overview for Dr. Viktor Yarotskyy

  • Neuronal ion channel biophysics, physiology, pharmacology, and structure–function relationships
  • Cellular and molecular mechanisms of synthetic opioid neurotoxicity
  • Cellular and molecular mechanisms of HIV-associated neurocognitive disorders (HAND)