Pharmacology & Toxicology Research
Cardiovascular
Overview
- Cardiovascular diseases are the leading cause of deaths globally.
- Our faculty include researchers focused on better understanding causes of cardiovascular diseases and identifying novel pharmacological targets in treating such diseases.
Research Approaches
- Atherogenesis
- hypertension and renal injury
- obesity-related damage
- vascular cell signaling
Faculty Research Interests
Guangbi (George) Li, Ph.D., Assistant Professor
Detailed research overview for Dr. Guangbi Li
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Exosome-mediated intercellular communication in glomerular disease.
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Renal medullary regulation of blood pressure by telocyte-derived exosomes.
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Podocyte Piezo1 channel in mechanosensing of glomerular hyperfiltration.
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Ceramide metabolism in podocytopathy and nephrotic syndrome.
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TRPML1 channel in lysosomal regulation of exosome release.
Ningjun Li, Ph.D., Professor
Detailed research overview for Dr. Ningjun Li
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- Renal sphingolipid signaling and hypertension
- Sphingosine kinases in cisplatin-induced nephrotoxicity
- Endocannabinoid system in kidney injury and disease progression
- Renal α7 nicotinic acetylcholine receptor function
- Fructose-induced salt-sensitive hypertension and hypoxia signaling
Pin-Lan Li, M.D., Ph.D., Professor
Detailed research overview for Dr. Pin-Lan Li
- Molecular mechanisms of podocytopathy and associated hypertension.
- Blood pressure regulation by endocannabinoid and exosomes in the renal medulla.
- Lipid raft redox signaling platforms in coronary endothelial cells.
- Inflammasome activation in hyperhomocysteinemia-induced glomerular disease.
- Novel second messengers – cADP-ribose and NAADP in arterial myocytes