Fan Zhang, M.D., Ph.D.

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Fan ZhangAssistant professor
Molecular Medicine Research Building, Room 3048
1220 East Broad Street
Box 980613
Richmond, Virginia 23298-0613
Phone: (804) 828-4754


  • M.D., Tongji Medical University, China, 1999
  • Ph.D., Tongji Medical College, Huazhong University of Science and Technology, China, 2002

Research interests

  • NAADP-mediated calcium signaling pathway
  • Pathophysiology of lysosome dysfunction
  • NAD(P)H oxidase related redox signaling and pathobiology
  • Transient receptor potential -ML channel function

Selected publications

Li PL, Zhang Y, Abais JM, Ritter JK, Zhang F. Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases. Messenger (Los Angel). 2013 Jun 1;2(2):63-85. PMID: 24749015

Zhu Q, Wang Z, Xia M, Li PL, Zhang F, Li N. Overexpression of HIF-1<alpha> Transgene in the Renal Medulla Attenuated Salt Sensitive Hypertension in Dahl S Rats. Biochim Biophys Acta. 2012 Jun;1822(6):936-41.

Zhang F, Xu M, Han WQ, Li PL Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells. Am J Physiol Cell Physiol. 2011 Aug;301(2):C421-30.

Zhang F, Xia M and Li PL. Lysosome-dependent Ca2+ release response to Fas activation in coronary arterial myocytes through NAADP: Evidence from CD38 gene knockouts. Am J Physiol- Heart Cell Physiol. 298(5):C1209-16, 2010.

Zhang F, Jin S, Yi F, Li PL. TRP-ML1 Functions as a Lysosomal NAADP-Sensitive Ca2+ Release Channel in Coronary Arterial Myocytes. J Cell Mol Med 13(9B):3174-85, 2009.

Zhang F, Jin S, Yi F, Xia M, Dewey WL, Li PL. Local production of O2∙ˉ by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal  20(4):637-44, 2008.

Jin S, Yi F, Zhang F, Poklis JL, Li PL. Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells. Arterioscler Thromb Vasc Biol  28(11):2056-62, 2008.

Zhang F, Li PL. Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats. J Biol Chem   282(35):25259-25269, 2007.

Zhang G, Zhang F, Muh R, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial myocytes. Am J Physiol Heart Circ Physiol  292(1):H483-95, 2007.

Zhang F, Zhang G, Zhang AY, Koeberl MJ, Wallander E, Li PL. Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes. Am J Physiol Heart Circ Physiol   291(1): H274-82, 2006.

Zhang F, Siow YL, O K. Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney. Kidney Int  65(4): 1327-1338, 2004.