Yang Zhang, Ph.D.
Molecular Medicine Research Building, Room 3016
1220 East Broad Street
P.O. Box 980613
Richmond, Virginia 23298-0613
Phone: (804) 628-3765
Fax: (804) 828-4794
- Ph.D., Medical College of Wisconsin, 2006
The goal of my research is to study the pathogenesis of cardiovascular and pulmonary diseases and related signal transduction mechanisms, which may ultimately lead to discovery of novel therapeutic targets of these diseases. Current projects are designed to study the role of NOX (NADPH oxidase), NOS (nitric oxide synthase) gene family enzymes and sphingolipids metabolizing enzymes in these diseases by using transgenic mouse models, RNA interference, fluorescent imaging and pharmacological interventions.
Zhang Y, Li X, Carpinteiro A, Jeremy AG, Soddemann M and Gulbins E. (2011) Kinase suppressor of ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat Med. 17:341-346.
Li X, Hong S, Li PL and Zhang Y. (2011) Docosahexanoic acid-induced coronary arterial dilation: Actions of 17S-hydroxy docosahexanoic acid on K+ channel activity. Journal of Pharmacology and Experimental Therapeutics. 336:891-899.
Perrotta C, Bizzozero L, Cazzato D, Morlacchi S, Assi E, Simbari F, Zhang Y, Gulbins E, Bassi MT, Rosa P and Clementi E. (2010) Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. Journal of Biological Chemistry. 285:40240-40251.
Li X, Becker KA and Zhang Y. (2010) Ceramide in redox signaling and cardiovascular diseases. Cellular Physiology and Biochemistry. 26:41-48.
Zhang Y, Li X, Grassmé H, Döring G and Gulbins E. (2011) Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages upon infection. Journal of Immunology. 184:5104-5111.
Zhang F, Zhang Y (co-first author) and Li PL. (2009) Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase. Microvascular Research. 78:45-50.
Zhang Y, Li X, Becker KA and Gulbins E. (2009) Ceramide-enriched membrane domains-structure and function. Biochimeca et Biophysica Acta. 1788:178-183.
Zhang Y, Li X, Carpinteiro A and Gulbins E. (2008) Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis. Journal of Immunology. 181:4247-4254.
Jin S, Zhang Y (co-first author), Yi F and Li PL. (2008) Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology. 28:485-490.
Zhang Y, Yi F, Jin S, Xia M, Chen QZ, Gulbins E and Li PL. (2007) Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells. Antioxidants and Redox Signaling. 9:817-828.
Zhang Y, Yi F, Zhang G, Gulbins E and Li PL. (2006) Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Hypertension. 47:74-80.
Zhang Y and Li PL. (2006) Vascular physiology of a Ca2+ mobilizing second messenger-cyclic ADP-ribose. Journal of Cellular and Molecular Medicine. 10:407-422.
Zhang Y, Teggatz EG, Zou AP, Campbell WB and Li PL. (2005) Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2 production in the intact coronary endothelium. American Journal of Physiology – Heart and Circulatory Physiology. 288:H686-694.
Zhang Y, Yi F, Teggatz EG, Zou AP and Li PL. (2004) Enhanced production and action of cyclic ADP-ribose during oxidative stress in small bovine coronary arterial smooth muscle. Microvascular Research. 67:159-167.
Zhang Y, Chen YF, Zhang DX, Yi FX, Qi J, Andrade-Gordon P, de Garavilla L, Li PL and Zou AP. (2003) Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney. American Journal of Physiology – Renal Physiology. 285:F792-798.