S. Stevens Negus, Ph.D.
- Ph.D., neurobiology. University of North Carolina, 1990
- Pharmacology of the analgesic and abuse-related effects of opioid analgesics
- Development of medications to treat opioid and CNS stimulant addiction
- Development of novel procedures to assess analgesia and drug reinforcement
- Strategies for assessment of drug interactions
Morphine-like opioid drugs are widely used to treat strong pain, but their use is limited by side effects that include high-abuse liability. Our laboratory is engaged in research to study factors that influence these pain-killing and abuse-related effects of opioids. Our studies are giving us new insights into the mechanisms and potential interactions of pain and addiction, and we are also pioneering new strategies for development of safer analgesics with reduced abuse liability.
This central theme of our work has also stimulated research in three other directions. First, we are working with medicinal chemistry colleagues to develop new medications that might be used to treat abuse of opioids and of CNS stimulants like cocaine. Second, we are developing novel and more sophisticated procedures to measure behaviors related to pain and addiction. Finally, our work has led us to develop and refine experimental strategies for the study of drug interactions.
Selected References (Reverse Chronology)
DRUG ABUSE AND ITS TREATMENT
Banks ML, Negus SS. Insights from preclinical choice models on treating drug addiction. Trends Pharmacol Sci, 2016; in press. PMC Journal-In process
Negus SS, Henningfield J. Agonist medications for the treatment of cocaine use disorder. Invited “Circumspectives” Article: Neuropsychopharmacology, 2015; 40:1815-1825. PMCID: PMC4839506
Negus SS, Miller LL. Intracranial self-stimulation (ICSS) to evaluate abuse potential of drugs. Pharmacol Rev, 2014; 66:869-917. PMCID: PMC4081730
Primary Research Articles
Banks ML, Negus SS. Repeated 7-day treatment effects with the 5-HT2C agonist lorcaserin and the 5-HT2A antagonist pimavanserin alone or in combination on cocaine vs. food choice in rhesus monkeys. Neuropsychopharmacology, 2016; in press. PMC Journal-In process.
Lazenka MF, Suyama JS, Bauer CT, Banks ML, Negus SS. Sex differences in abuse-related neurochemical and behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacol Biochem Behav, 2016; In press. PMC Journal-In process. In Special Issue on Sex Differences in Psychopharmacology
Johnson AR, Banks ML, Blough BE, Lile JA, Nicholson KL, Negus SS. Development of a translational model to screen medications for cocaine use disorder I: Choice between cocaine and food in rhesus monkeys. Drug Alcohol Depend, 2016; 165:103-110. PMCID: PMC4939093
Bonano JS, Glennon RA, De Felice LJ, Banks ML, Negus SS. Abuse-related and abuse-limiting effects of methcathinone and the “bath salts” cathinone derivatives methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats. Psychopharmacology, 2014; 231:199-207. PMCID: PMC3877726
PAIN AND ITS TREATMENT
Negus SS. Expression and treatment of pain-related behavioral depression. Lab Animal, 2013; 42:292-300. PMC Journal-In process
Negus SS, Altarifi AA. Mu, delta and kappa opioid agonist effects in novel assays of pain-depressed behavior. In: Ko H, Husbands, S, editors. Research and Development of Opioid-Related Ligands. American Chemical Society, Washington, DC. 2013, pp. 163-176. DOI: 10.1021/bk-2013-1131.ch009
Negus SS, Bilsky EJ, Pereira Do Carmo G, Stevenson GW. Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia. In: Szallasi A, editor. Methods in Molecular Biology: Analgesia. Humana Press, New York, 2010; pp. 79-91.
Primary Research Articles
Leitl MD, Negus SS. Pharmacological modulation of neuropathic pain-related depression of behavior: Effects of morphine, ketoprofen, bupropion and ∆9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. Behav Pharmacol, 2016; 27:364-376. PMCID: PMC4842121
Negus SS, Neddenriep B, Altarifi AA, Carroll FI, Leitl MD, Miller LL. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain, 2015; 156:1153-1160. PMCID: PMC4766843
Altarifi AA, Negus SS. Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats. Eur J Pharmacol, 2015; 748:76-82. PMCID: PMC4314312
Miller LL, Leitl MD, Banks ML, Blough BE, Negus SS. Effects of the triple monoamine uptake inhibitor amitifadine on pain-related depression of behavior and mesolimbic dopamine release in rats. Pain, 2015; 156:175-84. PMCID: PMC4351716