Laxmikant Deshpande, Ph.D.
Laxmikant S. Deshpande, Ph.D.
Kontos Medical Sciences Building, Room 615
1217 East Marshall Street
Richmond, Virginia 23298-0613
Phone: (804) 828-3392
• Virginia Commonwealth University, Ph.D., 2006
• Organophosphate Neurotoxicity
• Acquired Epilepsy and co-morbidities (depression, and cognitive deficits)
• Calcium signaling, anti-epileptic drugs, cannabinoids
Understanding the molecular bases of disorders of neuronal excitability has been the underlying theme of our research. Under the purview of the DOD Gulf-War Illness Research Program and the NIH CounterACT Research Program, we are identifying calcium-signaling based therapeutics for the effective treatment of immediate and long-term neurological consequences of pesticide exposures. My laboratory is committed to scientific education and research and we welcome students and investigators who would like to partner with us on this mission. Please visit our lab website for further details.
1. Phillips KF, Deshpande LS. Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness. Neurotoxicology. 2016 Jan; 52: 127-33.
2. Deshpande LS, Blair RE, Phillips KF, DeLorenzo RJ. Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication. Ann N Y Acad Sci. 2016 Jun; 1374 (1):176-83.
3. Blair RE, Deshpande LS, DeLorenzo RJ. Cannabinoids: is there a potential treatment role in epilepsy? Expert Opin Pharmacother. 2015; 16 (13):1911-4.
4. Deshpande LS, Phillips K, Huang B, DeLorenzo RJ. Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity. Neurotoxicology. 2014 Sep; 44: 352-7.
5. Deshpande LS, Carter DS, Blair RE, DeLorenzo RJ. Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate. Toxicol Sci. 2010 Aug; 116(2):623-31.